Yohimbine

Sexual HealthPrescription drug (research listing)

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Overview

Yohimbine is an indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina. It has a role as a dopamine receptor D2 antagonist, an alpha-adrenergic antagonist and a serotonergic antagonist. It is functionally related to a yohimbic acid.

Source: ChEBI (CC BY 4.0), via PubChem.

PubChem record: CID 8969 · Yohimbine
Molecular formula · weight: C21H26N2O3 · 354.4 g/mol
PubMed papers naming it (title/abstract): 8,054 search: “Yohimbine”
Registered clinical studies (ClinicalTrials.gov): 51 intervention: “Yohimbine”

Reference facts checked 2026-11-09. Counts are search results, not a judgement of the evidence.

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