VIP
ImmuneAlso known as: Vasoactive intestinal peptide, Vasoactive intestinal polypeptide
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Overview
VIP is a 28-amino-acid neuropeptide found in the nervous, endocrine, and immune systems. In research contexts, it is studied for signaling roles involving smooth muscle, secretion, circadian biology, and immune modulation.
Mechanism of Action
VIP signals primarily through VPAC1 and VPAC2 G protein-coupled receptors, increasing intracellular cAMP in responsive cells. These receptor pathways are used to study neuroimmune communication, vasoregulatory signaling, and peptide-mediated cellular responses.
Common Research Uses
- Neuropeptide signaling research
- VPAC receptor studies
- Immune modulation research
- Circadian pathway studies
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