Taltirelin

Overview

Taltirelin is an oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy. It has a role as an analgesic, a neuroprotective agent and a nootropic agent.

Source: ChEBI (CC BY 4.0), via PubChem.

PubChem record

CID 114750 · Taltirelin

Molecular formula · weight

C17H23N7O5 · 405.4 g/mol

PubMed papers naming it (title/abstract)

65 search: “Taltirelin”

Registered clinical studies (ClinicalTrials.gov)

1 intervention: “Taltirelin”

Reference facts checked 2026-11-09. Counts are search results, not a judgement of the evidence.