Orlistat

Overview

Orlistat is a carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. It has a role as an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, an EC 2.3.1.85 (fatty acid synthase) inhibitor, an anti-obesity agent and a bacterial metabolite. It is a member of formamides, a L-leucine derivative, a carboxylic ester and a beta-lactone.

Source: ChEBI (CC BY 4.0), via PubChem.

PubChem record

CID 3034010 · Orlistat

Molecular formula · weight

C29H53NO5 · 495.7 g/mol

PubMed papers naming it (title/abstract)

2,429 search: “Orlistat”

Registered clinical studies (ClinicalTrials.gov)

84 intervention: “Orlistat”

Reference facts checked 2026-11-09. Counts are search results, not a judgement of the evidence.