← Peptide Index/MOTS-c

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MOTS-c

Longevity

Also known as: MOTS c

🧪 Reconstitution Guide for MOTS-c

Dose calculator, BAC water volumes, and syringe unit tables.

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💰 Vendor Pricing Comparison

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Overview

MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c) is a 16 amino acid peptide encoded within the mitochondrial genome—one of the first identified mitochondria-derived peptides (MDPs). It acts as a peptide hormone regulating cellular metabolism, insulin sensitivity, and aging-associated stress responses.

Mechanism of Action

MOTS-c is produced in mitochondria and translocates to the nucleus under metabolic or oxidative stress, where it activates AMPK signaling and regulates folate-methionine cycle genes. This leads to improved insulin sensitivity, enhanced exercise tolerance, and modulation of aging-related gene expression pathways.