Memantine

Overview

Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. It has a role as an antidepressant, an antiparkinson drug, a dopaminergic agent, a NMDA receptor antagonist and a neuroprotective agent. It is a primary aliphatic amine and a member of adamantanes. It is a conjugate base of a memantinium(1+). It derives from a hydride of an adamantane.

Source: ChEBI (CC BY 4.0), via PubChem.

PubChem record

CID 4054 · Memantine

Molecular formula · weight

C12H21N · 179.30 g/mol

PubMed papers naming it (title/abstract)

4,876 search: “Memantine”

Registered clinical studies (ClinicalTrials.gov)

271 intervention: “Memantine”

Reference facts checked 2026-11-09. Counts are search results, not a judgement of the evidence.