GS-441524

Overview

GS-441524 is a C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV. It has a role as an anticoronaviral agent, an antiviral agent and a drug metabolite. It is a nitrile, an aromatic amine, a C-nucleoside and a pyrrolotriazine.

Source: ChEBI (CC BY 4.0), via PubChem.

PubChem record

CID 44468216 · Gs-441524

Molecular formula · weight

C12H13N5O4 · 291.26 g/mol

PubMed papers naming it (title/abstract)

267 search: “GS-441524”

Registered clinical studies (ClinicalTrials.gov)

10 intervention: “GS-441524”

Reference facts checked 2026-11-09. Counts are search results, not a judgement of the evidence.