Follistatin 344

Overview

Follistatin 344 is a 344 amino acid isoform of follistatin, a glycoprotein that acts as a high-affinity antagonist of activin, myostatin, and related TGF-β superfamily members. By inhibiting myostatin—the primary negative regulator of skeletal muscle mass—it has attracted research interest for muscle hypertrophy and recovery.

Mechanism of Action

Follistatin 344 binds myostatin (GDF-8) and activin with high affinity, preventing their interaction with activin type II receptors. This blocks SMAD2/3 signaling, disinhibiting muscle satellite cell activation and protein synthesis. The result is enhanced muscle fiber hypertrophy, improved regeneration, and increased muscle mass.

Common Research Uses

• Muscle hypertrophy research
• Myostatin inhibition studies
• Muscle wasting disease research
• Recovery and regeneration research
• Body composition studies

Vendors That Carry Follistatin 344