Dutasteride

Overview

Dutasteride is an aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. It has a role as an EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor and an antihyperplasia drug. It is an aza-steroid, a delta-lactam and a member of (trifluoromethyl)benzenes. It derives from a hydride of a 5alpha-androstane.

Source: ChEBI (CC BY 4.0), via PubChem.

PubChem record

CID 6918296 · Dutasteride

Molecular formula · weight

C27H30F6N2O2 · 528.5 g/mol

PubMed papers naming it (title/abstract)

1,285 search: “Dutasteride”

Registered clinical studies (ClinicalTrials.gov)

143 intervention: “Dutasteride”

Reference facts checked 2026-11-09. Counts are search results, not a judgement of the evidence.