AOD-9604
MetabolicAlso known as: AOD9604, AOD 9604, HGH Fragment 177-191
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Overview
AOD-9604 (Anti-Obesity Drug 9604) is a synthetic peptide fragment corresponding to amino acids 177–191 of human growth hormone with a tyrosine residue added at the N-terminus. Originally developed by Monash University for obesity treatment, it reached Phase 2b clinical trials and demonstrated lipolytic activity in both animal and human studies.
Mechanism of Action
AOD-9604 stimulates lipolysis in adipocytes and inhibits lipogenesis through β3-adrenergic signaling, mirroring the fat-metabolizing region of HGH. It operates independently of the IGF-1/insulin axis, avoiding the diabetogenic effects associated with full-length growth hormone.
Common Research Uses
- Fat loss and lipolysis research
- Metabolic health studies
- Body composition optimization
- Obesity research
- Cartilage and bone repair research
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